DefinitionChloride is a type of electrolyte. It works with other electrolytes such as potassium, sodium, and carbon dioxide (CO2). These substances help keep the proper balance of body fluids and maintain the body's acid-base balance. Show
This article is about the laboratory test used to measure the amount of chloride in the fluid portion (serum) of the blood. Alternative NamesSerum chloride test How the Test is PerformedA blood sample is needed. Most of the time blood is drawn from a vein located on the inside of the elbow or the back of the hand. How to Prepare for the TestMany medicines can interfere with blood test results.
Why the Test is PerformedYou may have this test if you have signs that your body's fluid level or acid-base balance is disturbed. This test is most often ordered with other blood tests, such as a basic or comprehensive metabolic panel. Normal ResultsA typical normal range is 96 to 106 milliequivalents per liter (mEq/L) or 96 to 106 millimoles per liter (millimol/L). Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results. The example above shows the common measurement range for results for these tests. Some laboratories use different measurements or may test different specimens. What Abnormal Results MeanA greater-than-normal level of chloride is called hyperchloremia. It may be due to:
A lower-than-normal level of chloride is called hypochloremia. It may be due to:
This test may also be done to help rule out or diagnose:
ReferencesGiavarina D. Blood biochemistry: measuring major plasma electrolytes. In: Ronco C, Bellomo R, Kellum JA, Ricci Z, eds. Critical Care Nephrology. 3rd ed. Philadelphia, PA: Elsevier; 2019:chap 54. Seifter JR. Acid-base disorders. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 118. Tolwani AJ, Saha MK, Wille KM. Metabolic acidosis and alkalosis. In: Vincent J-L, Abraham E, Moore FA, Kochanek PM, Fink MP, eds. Textbook of Critical Care. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 104. You may have heard of electrolytes and the role they play in keeping you hydrated and healthy. One of the most important of these electrically charged minerals is chloride. It works with other electrolytes, such as sodium and
potassium, to help balance acids and bases in your body. It also helps move fluid in and out of your cells. So if your chloride levels drop, you can become sick and dehydrated. If your levels are too high, it often means your kidneys aren’t working
properly. There is a simple blood test to measure your chloride levels. The results can tell if your levels are good or if they are out of balance. This will help your doctor figure out where to look for the condition or medication that might be causing your imbalance. You might hear this also called a “Cl test” or a “serum chloride test.” It’s usually ordered with other blood tests when you are having your cholesterol,
blood sugar, and other electrolytes such as sodium and potassium checked. If your doctor is concerned about the health of your heart or kidneys,
a chloride test can help explain what might be wrong. Your chloride levels can drop if you have had bouts of vomiting or diarrhea.
Diabetes can sometimes cause chloride levels to increase. If you’re having symptoms such as weakness, constant tiredness, or dehydration, your doctor may order a chloride test. You don’t need to
do anything special before a blood test. If you’re scheduled for a urine chloride test, you should avoid alcohol for at least 24 hours before giving a sample. The amount of fluids you drink before the test may affect the results, so ask
your doctor whether you should change anything about your fluid intake. Vomiting or diarrhea in the days before the test may lead to a lower chloride result. You should also tell your doctor all the prescription and over-the-counter medications you take, as well as any
vitamins or supplements. Some medications that may increase chloride levels include: You
may not need to change your medication routine. It’s just important that your doctor knows what you take, even if it’s aspirin for a headache. You will usually have a blood sample taken at your doctor’s office or a lab. Chloride levels also can be checked with a urine test. A lab tech will insert a needle into a vein in your arm to get the sample. Your arm may be a little sore where the blood was drawn. Some people become lightheaded for a few moments. You should be able to get the results of your test within a few days. It may be sooner if your doctor has ordered that the results be checked at once. The normal range for chloride in your blood is between 96 and 106 milliequivalents per liter (MEq/L). Some labs may vary in their definition of the normal range. Talk with your doctor about your test results, especially if you’re outside the healthy range.
Chloride levels tend to change if your sodium levels change, too. Chloride levels above 106 could point to kidney problems, such as renal tubular acidosis (when your kidneys aren’t removing enough acids from your blood and into your urine). Low levels have several other possible causes, including common, temporary problems such as vomiting and
dehydration. Among the more serious causes are: Testing the chloride levels in your blood or urine is practically painless and takes little time. The information it gives your doctor can help you avoid
some painful and serious health problems down the road. What causes high serum chloride levels?High levels of chloride may be a sign of: Dehydration. Kidney disease. Metabolic acidosis, a condition in which you have too much acid in your blood.
What condition is associated to Hyperchloremia?Nevertheless, hyperchloremia can occur when water losses exceed sodium and chloride losses, when the capacity to handle excessive chloride is overwhelmed, or when the serum bicarbonate is low with a concomitant rise in chloride as occurs with a normal anion gap metabolic acidosis or respiratory alkalosis.
|