What organ of the pregnant woman is central to the exchange of nutrients and waste products with the fetus?

References

Soo, JY, Wiese, MD, Berry, MJ, Morrison, JL. Does poor fetal growth influence the extent of fetal exposure to maternal medications? Pharmacol Res. 2018 130:7484.CrossRefGoogle ScholarPubMed

Jansson, T, Aye, ILMH, Goberdhan, DCI. The emerging role of mTORC1 signaling in placental nutrient-sensing. Placenta. 2012 33:e23–9.CrossRefGoogle ScholarPubMed

Poudel, R, McMillen, IC, Dunn, SL, Zhang, S, Morrison, JL. Impact of chronic hypoxemia on blood flow to the brain, heart, and adrenal gland in the late-gestation IUGR sheep fetus. Am J Physiol Regul Integr Comp Physiol. 2015 308:R151–62.CrossRefGoogle ScholarPubMed

Tan, W, Riggs, KW, Thies, RL, Rurak, DW. Use of an automated fluorescent microsphere method to measure regional blood flow in the fetal lamb. Can J Physiol Pharmacol. 1997 75:959–68.CrossRefGoogle ScholarPubMed

Morrison, JL, Carmichael, L, Homan, J, White, S, Richardson, BS. Cerebral blood flow during spontaneous and cholinergically induced behavioral states in the sheep fetus. Pediatr Res. 2005 57:667–73.CrossRefGoogle ScholarPubMed

Hope, ID, Huikeshoven, FJ, Gilbert, RD, Power, GG, Longo, LD. Errors in microsphere determination of cardiac output: a computer simulation in fetal sheep. Am J Physiol Circ Physiol. 1989 256:H302–10.CrossRefGoogle ScholarPubMed

Giussani, DA, Spencer, JA, Moore, PJ, Bennet, L, Hanson, MA. Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol. 1993 461:431–49.CrossRefGoogle ScholarPubMed

Bennet, L, Booth, LC, Ahmed-Nasef, N, et al. Male disadvantage? Fetal sex and cardiovascular responses to asphyxia in preterm fetal sheep. Am J Physiol Integr Comp Physiol. 2007 293:R1280–6.CrossRefGoogle ScholarPubMed

Morrison, JL, Chien, C, Riggs, KW, Gruber, N, Rurak, D. Effect of maternal fluoxetine administration on uterine blood flow, fetal blood gas status, and growth. Pediatr Res. 2002 51:433–42.CrossRefGoogle Scholar

Shalev, E, Dan, U, Weiner, E, et al. Prenatal diagnosis using sonographic guided cordocentesis. J Perinat Med. 1989;17:393–8.CrossRefGoogle ScholarPubMed

Mielke, G, Benda, N. Cardiac output and central distribution of blood flow in the human fetus. Circulation. 2001 103:1662–8.CrossRefGoogle ScholarPubMed

Barbera, A, Galan, HL, Ferrazzi, E, et al. Relationship of umbilical vein blood flow to growth parameters in the human fetus. Am J Obstet Gynecol. 1999 181:174–9.CrossRefGoogle ScholarPubMed

Jansz, MS, Seed, M, van Amerom, JFP, et al. Metric optimized gating for fetal cardiac MRI. Magn Reson Med. 2010 64:1304–14.CrossRefGoogle ScholarPubMed

Seed, M, van Amerom, JFP, Yoo, S-J, et al. Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study. J Cardiovasc Magn Reson. 2012 14:79.CrossRefGoogle ScholarPubMed

Prsa, M, Sun, L, van Amerom, J, et al. Reference ranges of blood flow in the major vessels of the normal human fetal circulation at term by phase contrast magnetic resonance imaging. Circ Cardiovasc Imaging. 2014 7:663–70.CrossRefGoogle ScholarPubMed

Longo, L. Respiration in the fetal-placental unit. In: Cowett, R, ed. Principles of Perinatal-Neonatal Metabolism. New York: Springer-Verlag New York Inc. 1991:304–15.Google Scholar

Longo, L. Respiratory gas exchange in the placenta. In: Fishman, A, Farhi, L, Tenney, S, eds. Handbook of Physiology, Sec 3. The Respiratory System, Vol. IV. Gas Exchange. Washington, DC: American Physiological Society. 1987:351401.Google Scholar

Soma-Pillay, P, Nelson-Piercy, C, Tolppanen, H, et al. Physiological changes in pregnancy. Cardiovasc J Afr. 2016 27:8994.CrossRefGoogle ScholarPubMed

Ouzounian, JG, Elkayam, U. Physiologic changes during normal pregnancy and delivery. Cardiol Clin. 2012 30:317–29.CrossRefGoogle ScholarPubMed

Goplerud, JM, Delivoria-Papadopoulos, M. Physiology of the placenta – gas exchange. Ann Clin Lab Sci. 1985 15:270–8.Google ScholarPubMed

Fujikura, T, Yoshida, J. Blood gas analysis of placental and uterine blood during cesarean delivery. Obstet Gynecol. 1996 87:133–6.CrossRefGoogle ScholarPubMed

Nye, GA, Ingram, E, Johnstone, ED, et al. Human placental oxygenation in late gestation: experimental and theoretical approaches. J Physiol. 2018 596:5523–34.CrossRefGoogle ScholarPubMed

Siggaard-Andersen, O, Huch, R. The oxygen status of fetal blood. Acta Anaesthesiol Scand. 1995 39:129–35.CrossRefGoogle Scholar

Soothill, PW, Nicolaides, KH, Rodeck, CH, Campbell, S. Effect of gestational age on fetal and intervillous blood gas and acid-base values in human pregnancy. Fetal Ther. 1986 1:168–75.CrossRefGoogle ScholarPubMed

Lackman, F, Capewell, V, Gagnon, R, Richardson, B. Fetal umbilical cord oxygen values and birth to placental weight ratio in relation to size at birth. Am J Obstet Gynecol. 2001 185:674–82.CrossRefGoogle ScholarPubMed

Manomayangkul, K, Siriussawakul, A, Nimmannit, A, et al. Reference values for umbilical cord blood gases of newborns delivered by elective cesarean section. J Med Assoc Thai. 2016 99:611–17.Google ScholarPubMed

Link, G, Clark, KE, Lang, U. Umbilical blood flow during pregnancy: evidence for decreasing placental perfusion. Am J Obstet Gynecol. 2007 196:489.e1-7.CrossRefGoogle ScholarPubMed

Helwig, JT, Parer, JT, Kilpatrick, SJ, Laros, J. Umbilical cord blood acid-base state: what is normal? Am J Obstet Gynecol. 1996 174:1807–14.CrossRefGoogle Scholar

Arikan, GM, Scholz, HS, Petru, E, et al. Cord blood oxygen saturation in vigorous infants at birth: what is normal? Br J Obstet Gynaecol. 2000 107:987–94.CrossRefGoogle Scholar

Sjostedt, S, Rooth, G, Caligara, F. The oxygen tension of the blood in the umbilical cord and the intervillous space. Arch Dis Child. 1960 35:529–33.CrossRefGoogle ScholarPubMed

Jopling, J, Henry, E, Wiedmeier, SE, Christensen, RD. Reference ranges for hematocrit and blood hemoglobin concentration during the neonatal period: data from a multihospital health care system. Pediatrics. 2009 123:e333–7.Google ScholarPubMed

Longo, LD, Power, GG, Forster, RE. Respiratory function of the placenta as determined with carbon monoxide in sheep and dogs. J Clin Invest. 1967 46:812–28.CrossRefGoogle Scholar

Longo, LD, Power, GG, Forster, RE. Placental diffusing capacity for carbon monoxide at varying partial pressures of oxygen. J Appl Physiol. 1969 26:360–70.CrossRefGoogle ScholarPubMed

Bissonnette, JM, Wickham, WK. Placental diffusing capacity for carbon monoxide in unanesthetized guinea pigs. Respir Physiol. 1977 31:161–8.CrossRefGoogle ScholarPubMed

Bacon, BJ, Gilbert, RD, Kaufmann, P, et al. Placental anatomy and diffusing capacity in guinea pigs following long-term maternal hypoxia. Placenta. 1984 5:475–87.CrossRefGoogle ScholarPubMed

Bissonnette, JM, Longo, LD, Novy, MJ, Murata, Y, Martin, CB. Placental diffusing capacity and its relation to fetal growth. J Dev Physiol. 1979 1:351–9.Google ScholarPubMed

Mayhew, TMM, Joy, CF, Haas, JD. Structure-function correlation in the human placenta: the morphometric diffusing capacity for oxygen at full term. J Anat. 1984 139:691708.Google ScholarPubMed

Longo, LD, Ching, KS. Placental diffusing capacity for carbon monoxide and oxygen in unanesthetized sheep. J Appl Physiol. 1977 43:885–93.CrossRefGoogle ScholarPubMed

Rocco, E, Bennett, T, Power, G. Placental diffusing capacity in unanesthetized rabbits. Am J Physiol Content. 1975 228:465–9.Google ScholarPubMed

Boyd, JD, Hamilton, WJ. Development and structure of the human placenta from the end of the 3rd month of gestation. Br J Obstet Gynaecol. 1967 74:161226.CrossRefGoogle ScholarPubMed

Jackson, MR, Mayhew, TM, Boyd, PA. Quantitative description of the elaboration and maturation of villi from 10 weeks of gestation to term. Placenta. 1992 13:357–70.CrossRefGoogle ScholarPubMed

Mayhew, TM, Jackson, MR, Boyd, PA. Changes in oxygen diffusive conductances of human placentae during gestation (10–41 weeks) are commensurate with the gain in fetal weight. Placenta. 1993 14:5161.CrossRefGoogle ScholarPubMed

Wilkening, RB, Meschia, G. Current topic: comparative physiology of placental oxygen transport. Placenta. 1992 13:115.CrossRefGoogle ScholarPubMed

Power, GG, Longo, LD, Wagner, N, Kuhl, DE, Forster, RE. Uneven distribution of maternal and fetal placental blood flow, as demonstrated using macroaggregates, and its response to hypoxia. J Clin Invest. 1967 46:2053–63.CrossRefGoogle ScholarPubMed

Power, GG, Dale, PS, Nelson, PS. Distribution of maternal and fetal blood flow within cotyledons of the sheep placenta. Am J Physiol. 1981 241:H486-96.Google ScholarPubMed

Nelson, PS, Gilbert, RD, Longo, LD. Fetal growth and placental diffusing capacity in guinea pigs following long-term maternal exercise. J Dev Physiol. 1983 5:110.Google ScholarPubMed

Meng, Q, Shao, L, Luo, X, et al. Ultrastructure of placenta of gravidas with gestational diabetes mellitus. Obstet Gynecol Int. 2015 2015:283124.CrossRefGoogle ScholarPubMed

Burton, GJ, Jauniaux, E. Pathophysiology of placental-derived fetal growth restriction. Am J Obstet Gynecol. 2018 218:S745–61.CrossRefGoogle ScholarPubMed

Mayhew, TM, Manwani, R, Ohadike, C, Wijesekara, J, Baker, PN. The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffusive conductances. Placenta. 2007 28:233–8.CrossRefGoogle ScholarPubMed

Power, GG, Jenkins, F. Factors affecting O2 transfer in sheep and rabbit placenta perfused in situ. Am J Physiol. 1975 229:1147–53.CrossRefGoogle ScholarPubMed

Young, DC, Popat, R, Luther, ER, Scott, KE, Writer, WDR. Influence of maternal oxygen administration on the term fetus before labor. Am J Obstet Gynecol. 1980 136:321–4.CrossRefGoogle ScholarPubMed

Longo, LD, Dale, PS, Gilbert, RD. Uteroplacental O2 uptake: continuous measurements during uterine quiescence and contractions. Am J Physiol Integr Comp Physiol. 1986 250:R1099–107.CrossRefGoogle ScholarPubMed

Battaglia, C, Artini, PG, D’Ambrogio, G, et al. Maternal hyperoxygenation in the treatment of intrauterine growth retardation. Am J Obstet Gynecol. 1992 167:430–5.CrossRefGoogle ScholarPubMed

Khatib, N, Thaler, I, Beloosesky, R, et al. The effect of maternal hyperoxygenation on fetal circulatory system in normal growth and IUGR fetuses: what we can learn from this impact. J Matern Neonatal Med. 2018 31:914–18.Google ScholarPubMed

Porayette, P, Madathil, S, Sun, L, et al. MRI reveals hemodynamic changes with acute maternal hyperoxygenation in human fetuses with and without congenital heart disease. Prenat Diagn. 2016 36:274–81.CrossRefGoogle ScholarPubMed

Presbitero, P, Somerville, J, Stone, S, et al. Pregnancy in cyanotic congenital heart disease: outcome of mother and fetus. Circulation. 1994 89:2673–6.CrossRefGoogle ScholarPubMed

Hutter, D, Kingdom, J, Jaeggi, E. Causes and mechanisms of intrauterine hypoxia and its impact on the fetal cardiovascular system: a review. Int J Pediatr. 2010 2010: 401323.CrossRefGoogle ScholarPubMed

Gelson, E, Johnson, M. Effect of maternal heart disease on pregnancy outcomes. Expert Rev Obstet Gynecol. 2010 5:605–17.CrossRefGoogle Scholar

McGillick, EV, Orgeig, S, Allison, BJ, et al. Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation. J Physiol. 2017 595:4329–50.CrossRefGoogle ScholarPubMed

Brain, KL, Allison, BJ, Niu, Y, et al. Induction of controlled hypoxic pregnancy in large mammalian species. Physiol Rep. 2015 3:113.CrossRefGoogle ScholarPubMed

Allison, BJ, Brain, KL, Niu, Y, et al. Fetal in vivo continuous cardiovascular function during chronic hypoxia. J Physiol. 2016 594:1247–64.CrossRefGoogle ScholarPubMed

Oh, C, Dong, Y, Harman, C, et al. Chronic hypoxia differentially increases glutathione content and γ-glutamyl cysteine synthetase expression in fetal guinea pig organs. Early Hum Dev. 2008 84:121–7.CrossRefGoogle ScholarPubMed

Botting, KJ, Loke, XY, Zhang, S, et al. IUGR decreases cardiomyocyte endowment and alters cardiac metabolism in a sex- and cause-of-IUGR-specific manner. Am J Physiol Integr Comp Physiol. 2018 315:R4867.CrossRefGoogle Scholar

Delivoria-Papadopoulos, M, McGowan, JE. Oxygen transport and delivery. In: Polin, RA, Fox, WW, Abman, SH, eds. Fetal and Neonatal Physiology. Philadelphia, PA: WB Saunders Company. 2004:880–9.Google Scholar

Hill, E, Power, G, Longo, L. A mathematical model of carbon dioxide transfer in the placenta and its interaction with oxygen. Am J Physiol Content. 1973 224:283–99.Google ScholarPubMed

Karamermer, Y, Roos-Hesselink, JW. Pregnancy and adult congenital heart disease. Expert Rev Cardiovasc Ther. 2007 5:859–69.CrossRefGoogle ScholarPubMed

Longo, LD. Maternal blood volume and cardiac output during pregnancy: a hypothesis of endocrinologic control. Am J Physiol Integr Comp Physiol. 1983 245:R720–9.CrossRefGoogle ScholarPubMed

Longo, LD, Hill, EP, Power, GG. Theoretical analysis of factors affecting placental O2 transfer. Am J Physiol. 1972 222:730–9.CrossRefGoogle Scholar

Wilkening, RB, Meschia, G. Fetal oxygen uptake, oxygenation, and acid-base balance as a function of uterine blood flow. Am J Physiol. 1983 244:H749-55.Google ScholarPubMed

Dawes, GS, Mott, JC. Changes in O2 distribution and consumption in foetal lambs with variations in umbilical blood flow. J Physiol. 1964 170:524–40.CrossRefGoogle ScholarPubMed

Clapp, JF. The relationship between blood flow and oxygen uptake in the uterine and umbilical circulations. Am J Obstet Gynecol. 1978 132:410–13.CrossRefGoogle ScholarPubMed

Browne, VA, Toledo-Jaldin, L, Davila, RD, et al. High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude. Am J Physiol Regul Integr Comp Physiol . 2011 300:R1221–9.CrossRefGoogle ScholarPubMed

Metcalfe, J, Romney, SL, Ramsey, LH, Reid, DE, Burwell, CS. Estimation of uterine blood flow in normal human pregnancy at term. J Clin Invest. 1955 34:1632–8.CrossRefGoogle ScholarPubMed

Assali, NS, Rauramo, L, Peltonen, T. Measurement of uterine blood flow and uterine metabolism. Am J Obstet Gynecol. 1960 79:8698.CrossRefGoogle ScholarPubMed

Konje, JC, Kaufmann, P, Bell, SC, Taylor, DJ. A longitudinal study of quantitative uterine blood flow with the use of color power angiography in appropriate for gestational age pregnancies. Am J Obstet Gynecol. 2001 185:608–13.CrossRefGoogle ScholarPubMed

Konje, JC, Howarth, ES, Kaufmann, P, Taylor, DJ. Longitudinal quantification of uterine artery blood volume flow changes during gestation in pregnancies complicated by intrauterine growth restriction. Br J Obstet Gynaecol. 2003 110:301–5.CrossRefGoogle ScholarPubMed

Maini, CL, Rosati, P, Galli, G, et al. Non-invasive radioisotopic evaluation of placental blood flow. Gynecol Obstet Invest. 1985 19:196206.CrossRefGoogle ScholarPubMed

Thaler, I, Manor, D, Itskovitz, J, et al. Changes in uterine blood flow during human pregnancy. Am J Obstet Gynecol. 1990 162:121–5.CrossRefGoogle ScholarPubMed

Ziegler, WF, Bernstein, I, Badger, G, Leavitt, T, Cerrero, ML. Regional hemodynamic adaptation during the menstrual cycle. Obstet Gynecol. 1999 94:695–9.Google ScholarPubMed

Beltrame, RT, Covre, C, Littig, LB, et al. Transrectal Doppler sonography of uterine blood flow in ewes during pregnancy. Theriogenology. 2017 91:5561.CrossRefGoogle ScholarPubMed

Elmetwally, M, Rohn, K, Meinecke-Tillmann, S. Noninvasive color Doppler sonography of uterine blood flow throughout pregnancy in sheep and goats. Theriogenology. 2016 85:1070–9.CrossRefGoogle ScholarPubMed

Elmetwally, M, Bollwein, H. Uterine blood flow in sheep and goats during the peri-parturient period assessed by transrectal Doppler sonography. Anim Reprod Sci. 2017 176:32–9.CrossRefGoogle ScholarPubMed

Ducas, RA, Elliott, JE, Melnyk, SF, et al. Cardiovascular magnetic resonance in pregnancy: insights from the cardiac hemodynamic imaging and remodeling in pregnancy (CHIRP) study. J Cardiovasc Magn Reson. 2014 16:1.CrossRefGoogle ScholarPubMed

Silver, M, Barnes, RJ, Comline, RS, Burton, GJ. Placental blood flow: some fetal and maternal cardiovascular adjustments during gestation. J Reprod Fertil Suppl. 1982 31:139–60.Google ScholarPubMed

Lotz, J, Meier, C, Leppert, A, Galanski, M. Cardiovascular flow measurement with phase-contrast MR imaging: basic facts and implementation. Radiographics. 2002 22:651–71.CrossRefGoogle ScholarPubMed

Saini, BS, Zhu, M, Portnoy, S, et al. OP29.07: Non‐invasive in utero measurements of placental oxygen transport using MRI. Ultrasound Obstet Gynecol. 2016 48:148.Google Scholar

Chung, M, Teng, C, Timmerman, M, Meschia, G, Battaglia, FC. Production and utilization of amino acids by ovine placenta in vivo. Am J Physiol. 1998 274:E13-22.Google ScholarPubMed

Rudolph, A. Congenital Diseases of the Heart: Clinical-Physiological Considerations. 3rd edn. Hoboken, NJ: Wiley-Blackwell. 2009.CrossRefGoogle Scholar

Kiserud, T, Ebbing, C, Kessler, J, Rasmussen, S. Fetal cardiac output, distribution to the placenta and impact of placental compromise. Ultrasound Obstet Gynecol. 2006 28:126–36.CrossRefGoogle ScholarPubMed

Sun, L, Macgowan, CK, Sled, JG, et al. Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Circulation. 2015 131:1313–23.CrossRefGoogle ScholarPubMed

Zhu, MY, Milligan, N, Keating, S, et al. The hemodynamics of late-onset intrauterine growth restriction by MRI. Am J Obstet Gynecol. 2016 214(3):367.e1-e17.CrossRefGoogle ScholarPubMed

Figueras, F, Fernández, S, Hernández-Andrade, E, Gratacós, E. Umbilical venous blood flow measurement: accuracy and reproducibility. Ultrasound Obstet Gynecol. 2008 32:587–91.CrossRefGoogle ScholarPubMed

Edelstone, DI, Rudolph, AM, Heymann, MA. Liver and ductus venosus blood flows in fetal lambs in utero. Circ Res. 1978 42:426–33.CrossRefGoogle ScholarPubMed

Meschia, G, Cotter, JR, Breathnach, CS, Barron, DH. The hemoglobin, oxygen, carbon dioxide and hydrogen ion concentrations in the umbilical bloods of sheep and goats as sampled via indwelling plastic catheters. Am J Obstet Gynecol. 1965 50:185–95.Google ScholarPubMed

Bessette, NW, Rurak, DW. Chronic fetal and maternal instrumentation in pregnant sheep: effect on gestation length and birthweight. Reprod Fertil Dev. 2010 22:459–67.CrossRefGoogle ScholarPubMed

Comline, RS, Silver, M. Daily changes in foetal and maternal blood of conscious pregnant ewes, with catheters in umbilical and uterine vessels. J Physiol. 1970 209:567–86.CrossRefGoogle ScholarPubMed

Morrison, JL, Botting, KJ, Dyer, JL, et al. Restriction of placental function alters heart development in the sheep fetus. Am J Physiol Regul Integr Comp Physiol. 2007 293:R306–13.CrossRefGoogle ScholarPubMed

Berman, W, Goodlin, RC, Heymann, MA, Rudolph, AM. Relationships between pressure and flow in the umbilical and uterine circulations of the sheep. Circ Res. 1976 38:262–6.CrossRefGoogle ScholarPubMed

Rurak, D, Bessette, NW. Changes in fetal lamb arterial blood gas and acid-base status with advancing gestation. Am J Physiol Regul Integr Comp Physiol. 2013 304:R908-16.CrossRefGoogle ScholarPubMed

Quintó, L, Aponte, JJ, Menéndez, C, et al. Relationship between haemoglobin and haematocrit in the definition of anaemia. Trop Med Int Heal. 2006 11:1295–302.Google ScholarPubMed

Carneiro, IA, Drakeley, CJ, Owusu-Agyei, S, Mmbando, B, Chandramohan, D. Haemoglobin and haematocrit: is the threefold conversion valid for assessing anaemia in malaria-endemic settings? Malar J. 2007 6:67.CrossRefGoogle ScholarPubMed

Rossi, A, Cornette, J, Johnson, MR, et al. Quantitative cardiovascular magnetic resonance in pregnant women: cross-sectional analysis of physiological parameters throughout pregnancy and the impact of the supine position. J Cardiovasc Magn Reson. 2011 13:31.CrossRefGoogle ScholarPubMed

Humphries, A, Mirjalili, SA, Tarr, GP, Thompson, JMD, Stone, P. The effect of supine positioning on maternal hemodynamics during late pregnancy. J Matern Neonatal Med. 2018 32(23):3923–30.Google ScholarPubMed

Power, G, Longo, L. Sluice flow in placenta: maternal vascular pressure effects on fetal circulation. Am J Physiol Content. 1973 225:1490–6.Google ScholarPubMed

Warland, J, Dorrian, J, Kember, AJ, et al. Modifying maternal sleep position in late pregnancy through positional therapy: a feasibility study. J Clin Sleep Med. 2018 14:1387–97.CrossRefGoogle ScholarPubMed

Warland, J, Dorrian, J, Morrison, JL, O’Brien, LM. Maternal sleep during pregnancy and poor fetal outcomes: a scoping review of the literature with meta-analysis. Sleep Med Rev. 2018 41:197219.CrossRefGoogle ScholarPubMed

Macara, L, Kingdom, JC, Kaufmann, P, et al. Structural analysis of placental terminal villi from growth-restricted pregnancies with abnormal umbilical artery Doppler waveforms. Placenta. 1996 17:3748.CrossRefGoogle ScholarPubMed

Todros, T, Sciarrone, A, Piccoli, E, et al. Umbilical Doppler waveforms and placental villous angiogenesis in pregnancies complicated by fetal growth restriction. Obstet Gynecol. 1999 93:499503.Google ScholarPubMed

Gu, W, Jones, CT, Parer, JT. Metabolic and cardiovascular effects on fetal sheep of sustained reduction of uterine blood flow. J Physiol. 1985 368:109–29.CrossRefGoogle ScholarPubMed

Owens, JA, Falconer, J, Robinson, JS. Effect of restriction of placental growth on umbilical and uterine blood flows. Am J Physiol. 1986 250:R427–34.Google ScholarPubMed

Morrison, JL. Sheep models of intrauterine growth restriction: fetal adaptations and consequences. Clin Exp Pharmacol Physiol. 2008 35:730–43.CrossRefGoogle ScholarPubMed

Zhang, S, Regnault, TRH, Barker, PL, et al. Placental adaptations in growth restriction. Nutrients. 2015 7:360–89.CrossRefGoogle ScholarPubMed

Zhang, S, Barker, P, Botting, KJ, et al. Early restriction of placental growth results in placental structural and gene expression changes in late gestation independent of fetal hypoxemia. Physiol Rep. 2016 4:119.CrossRefGoogle ScholarPubMed

Drenthen, W, Pieper, PG, Roos-Hesselink, JW, et al. Pregnancy and delivery in women after Fontan palliation. Heart. 2006 92:1290–4.CrossRefGoogle ScholarPubMed

Gelson, E, Curry, R, Gatzoulis, MA, et al. Effect of maternal heart disease on fetal growth. Obstet Gynecol. 2011 117:886–91.CrossRefGoogle ScholarPubMed

Parer, JT, De Lannoy, CW, Hoversland, AS, Metcalfe, J. Effect of decreased uterine blood flow on uterine oxygen consumption in pregnant macaques. Am J Obstet Gynecol. 1968 100:813–20.CrossRefGoogle ScholarPubMed

Chen, JZJ, Sheehan, PM, Brennecke, SP, Keogh, RJ. Vessel remodelling, pregnancy hormones and extravillous trophoblast function. Mol Cell Endocrinol. 2012 349:138–44.CrossRefGoogle ScholarPubMed

Harris, L. Review: trophoblast-vascular cell interactions in early pregnancy. How to remodel a vessel. Placenta. 2010 31:S93-8.CrossRefGoogle ScholarPubMed

Burton, G, Woods, A, Jauniaux, E, Kingdom, J. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta. 2009 30:473–82.CrossRefGoogle ScholarPubMed

Naeye, RL. Pregnancy hypertension, placental evidences of low uteroplacental blood flow, and spontaneous premature delivery. Hum Pathol. 1989 20:441–4.CrossRefGoogle ScholarPubMed

Stott, D, Papastefanou, I, Paraschiv, D, Clark, K, Kametas, NA. Longitudinal maternal hemodynamics in pregnancies affected by fetal growth restriction. Ultrasound Obstet Gynecol. 2017 49:761–8.CrossRefGoogle ScholarPubMed

Guy, GP, Ling, HZ, Machuca, M, Poon, LC, Nicolaides, KH. Maternal cardiac function at 35–37 weeks’ gestation: relationship with birth weight. Ultrasound Obstet Gynecol. 2017 49:6772.CrossRefGoogle ScholarPubMed

Melchiorre, K, Sutherland, GR, Liberati, M, Thilaganathan, B. Maternal cardiovascular impairment in pregnancies complicated by severe fetal growth restriction. Hypertension. 2012 60:437–43.CrossRefGoogle ScholarPubMed

Jouppila, P, Kirkinen, P. Umbilical vein blood flow in the human fetus in cases of maternal and fetal anemia and uterine bleeding. Ultrasound Med Biol. 1984 10:365–70.CrossRefGoogle ScholarPubMed

Cohn, HE, Sacks, EJ, Heymann, MA, Rudolph, AM. Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol. 1974 120:817–24.CrossRefGoogle ScholarPubMed

Adamsons, K, Beard, RW, Myers, RE. Comparison of the composition of arterial, venous, and capillary blood of the fetal monkey during labor. Am J Obstet Gynecol. 1970 107:435–40.CrossRefGoogle ScholarPubMed

Browne, VA, Stiffel, VM, Pearce, WJ, Longo, LD, Gilbert, RD. Cardiac beta-adrenergic receptor function in fetal sheep exposed to long-term high-altitude hypoxemia. Am J Physiol. 1997 273:R2022-31.Google ScholarPubMed

Ferrazzi, E, Rigano, S, Bozzo, M, et al. Umbilical vein blood flow in growth-restricted fetuses. Ultrasound Obstet Gynecol. 2000 16:432–8.CrossRefGoogle ScholarPubMed

Rigano, S, Bozzo, M, Padoan, A, et al. Small size-specific umbilical vein diameter in severe growth restricted fetuses that die in utero. Prenat Diagn. 2008 28:908–13.CrossRefGoogle ScholarPubMed

Grocott, MPW, Martin, DS, Levett, DZH, et al. Arterial blood gases and oxygen content in climbers on Mount Everest. N Engl J Med. 2009 360:140–9.CrossRefGoogle ScholarPubMed

Moore, LG, Charles, SM, Julian, CG. Humans at high altitude: hypoxia and fetal growth. Respir Physiol Neurobiol. 2011 178:181–90.CrossRefGoogle ScholarPubMed

Julian, CG, Galan, HL, Wilson, MJ, et al. Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude. Am J Physiol Integr Comp Physiol. 2008 295:R906–15.CrossRefGoogle ScholarPubMed

Moore, LG, Zamudio, S, Zhuang, J, Sun, S, Droma, T. Oxygen transport in Tibetan women during pregnancy at 3,658 m. Am J Phys Anthropol. 2001 114:4253.3.0.CO;2-B>CrossRefGoogle ScholarPubMed

Wilson, MJ, Lopez, M, Vargas, M, et al. Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents. Am J Physiol Regul Integr Comp Physiol. 2007 293:R1313–24.CrossRefGoogle ScholarPubMed

Chen, D, Zhou, X, Zhu, Y, Zhu, T, Wang, J. Comparison study on uterine and umbilical artery blood flow during pregnancy at high altitude and at low altitude. Zhonghua Fu Chan Ke Za Zhi. 2002 37:6971.Google Scholar

Julian, CG, Wilson, MJ, Lopez, M, et al. Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth. Am J Physiol Regul Integr Comp Physiol . 2009 296:R1564–75.CrossRefGoogle ScholarPubMed

Postigo, L, Heredia, G, Illsley, NP, et al. Where the O2 goes to: preservation of human fetal oxygen delivery and consumption at high altitude. J Physiol. 2009 587:693708.CrossRefGoogle ScholarPubMed

Powell, A, Maier, S, Chung, T, Geva, T. Phase-velocity cine magnetic resonance imaging measurement of pulsatile blood flow in children and young adults: in vitro and in vivo validation. Pediatr Cardiol. 2000 21:104–10.CrossRefGoogle Scholar

Sun, L, Macgowan, CK, Portnoy, S, et al. New advances in fetal cardiovascular magnetic resonance imaging for quantifying the distribution of blood flow and oxygen transport: potential applications in fetal cardiovascular disease diagnosis and therapy. Echocardiography. 2017 34:1799–803.CrossRefGoogle ScholarPubMed

Portnoy, S, Osmond, M, Zhu, MY, et al. Relaxation properties of human umbilical cord blood at 1.5 Tesla. Magn Reson Med. 2017 77:1678–90.CrossRefGoogle ScholarPubMed

Portnoy, S, Milligan, N, Seed, M, Sled, JG, Macgowan, CK. Human umbilical cord blood relaxation times and susceptibility at 3 T. Magn Reson Med. 2018 79:3194–206.CrossRefGoogle ScholarPubMed

Portnoy, S, Seed, M, Sled, JG, Macgowan, CK. Non-invasive evaluation of blood oxygen saturation and hematocrit from T1 and T2 relaxation times: in-vitro validation in fetal blood. Magn Reson Med. 2017 78:2352–9.CrossRefGoogle ScholarPubMed

Seed, M. Advanced fetal cardiac MR Imaging. In: Kline-Fath, BM, Bulas, DI, Bahado-Singh, R, eds. Fundamental and Advanced Fetal Imaging: Ultrasound and MRI. Wolters Kluwer Health. 2015:228–34.Google Scholar

Jones, HN, Olbrych, SK, Smith, KL, et al. Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Placenta. 2015 36:1078–86.CrossRefGoogle ScholarPubMed

Matthiesen, NB, Henriksen, TB, Agergaard, P, et al. Congenital heart defects and indices of placental and fetal growth in a nationwide study of 924 422 liveborn infants. Circulation. 2016 134:1546–56.CrossRefGoogle Scholar

Hodgkinson, CP. Physiology of the ovarian veins during pregnancy. Obstet Gynecol. 1953 1:2637.Google ScholarPubMed

Bonds, DR, Crosby, LO, Cheek, TG, et al. Estimation of human fetal-placental unit metabolic rate by application of the Bohr principle. J Dev Physiol. 1986 8:4954.Google ScholarPubMed

Meschia, G, Battaglia, FC, Hay, WW, Sparks, JW. Utilization of substrates by the ovine placenta in vivo. Fed Proc. 1980 39:245–9.Google ScholarPubMed

Owens, J, Falconer, J, Robinson, J. Effect of restriction of placental growth on oxygen delivery to and consumption by the pregnant uterus and fetus. J Dev Physiol. 1987 9:137–50.Google ScholarPubMed

Campbell, GM, Dawes, GS, Fishman, AP, Hyman, AI, James, GB. The oxygen consumption of the placenta and foetal membranes in the sheep. J Physiol. 1966 182:439–64.CrossRefGoogle ScholarPubMed

Koos, BJ. Central stimulation of breathing movements in fetal lambs by prostaglandin synthetase inhibitors. J Physiol. 1985 362:455–66.CrossRefGoogle ScholarPubMed

Dawes, GS, Fox, HE, Leduc, BM, Liggins, GC, Richards, RT. Respiratory movements and rapid eye movement sleep in the foetal lamb. J Physiol. 1972 220:119–43.CrossRefGoogle ScholarPubMed

te Pas, AB, Davis, PG, Hooper, SB, Morley, CJ. From liquid to air: breathing after birth. J Pediatr. 2008 152:607–11.CrossRefGoogle ScholarPubMed

Donnelly, L, Campling, G. Functions of the placenta. Anaesth Intensive Care Med. 2014 15:136–9.CrossRefGoogle Scholar

What organ of the pregnant woman is central to the exchange of nutrients for waste products with the fetus quizlet?

The fetus is connected by the umbilical cord to the placenta. This is the organ that develops and implants in the mother's uterus during pregnancy. Through the blood vessels in the umbilical cord, the fetus gets all needed nutrition and oxygen. The fetus gets life support from the mother through the placenta.

What organ is responsible for nutrient and waste exchange in a developing fetus?

The placenta is a large organ that develops during pregnancy. It is attached to the wall of the uterus, usually at the top or side. The umbilical cord connects the placenta to your baby. Blood from the mother passes through the placenta, filtering oxygen, glucose and other nutrients to your baby via the umbilical cord.

What is the organ that is used to transfer nutrients to a fetus?

The placenta is an organ that develops in the uterus during pregnancy. This structure provides oxygen and nutrients to a growing baby. It also removes waste products from the baby's blood. The placenta attaches to the wall of the uterus, and the baby's umbilical cord arises from it.

What organ supplies the fetus with nutrients?

The fetus is connected by the umbilical cord to the placenta, the organ that develops and implants in the mother's uterus during pregnancy. Through the blood vessels in the umbilical cord, the fetus receives all the necessary nutrition, oxygen, and life support from the mother through the placenta.